Top 12 EHR Integration Companies, Platforms, and APIs (2025)

If you’re building digital health products or streamlining hospital operations, chances are your roadmap hinges on clean, reliable connections to EHRs. That’s where projects stall: HL7 v2 and FHIR mapping, patient matching, writebacks vs. read-only, per-interface fees, vendor security reviews, and months of testing across Epic, Oracle Health, MEDITECH, and more. Some vendors move data but don’t support orders, scheduling, or claims. Others boast networks but lack fine-grained workflow integration. And pricing models can spike as volumes grow. Choosing the right partner can mean the difference between a 6-week launch and a 6-month slog.

This guide cuts through the noise. We’ve curated the top 12 EHR integration companies, platforms, and APIs for 2025—spanning connectivity engines, developer-friendly APIs, patient record networks, and EHR-native options. For each vendor, you’ll see what it is, key capabilities, standards supported (FHIR R4/R5, HL7 v2, CCDA, X12, SMART on FHIR), ideal use cases and buyers, plus pricing and contract notes. Use it to build a shortlist, align stakeholders, and pick the best fit with confidence.

1. VectorCare Connect

VectorCare Connect is the EHR integration fabric of VectorCare’s patient‑logistics platform, unifying EHR, CAD, and billing so teams coordinate transport, home care, and DME in one flow. It pairs connectivity with workflow control to cut rework and phone time while powering AI dispatch and analytics.

What it is

Managed interoperability linking VectorCare workflows with clinical and financial systems.

Key capabilities

• Orders/scheduling/status/message sync
• Vendor policy enforcement
• ADI automations (dispatch, billing)

Integrations and standards supported

Connects to EHRs, CAD, and billing via your existing interface engines/APIs; endpoints and formats are scoped per project.

Ideal use cases and buyers

Hospitals, EMS/NEMT, home health, DME, and public agencies managing high‑volume transitions of care.

Pricing and contract notes

Custom enterprise pricing; often bundled with Hub, Trust, Pay, Insights, or ADI; scope‑based.

2. Redox

Among EHR integration companies, Redox is a go-to platform for normalizing health-system interfaces so products can send, receive, process, and act on real-time data at scale without rebuilding connections for every site.

What it is

A cloud interoperability platform that standardizes connectivity to healthcare systems and apps.

Key capabilities

• Unified connectivity: Abstracts disparate interfaces into a consistent integration experience.
• Real-time exchange: Send/receive and process high-volume clinical and admin data streams.
• Observability and security: Monitoring, alerting, and controls for PHI-grade operations.

Integrations and standards supported

Connects with leading EHRs and third-party systems; supports common healthcare data formats and patterns. Specific endpoints, formats, and message types are finalized during implementation.

Ideal use cases and buyers

• Digital health vendors scaling across multiple health systems
• Health systems/IDNs seeking a standardized external connectivity layer

Pricing and contract notes

Quote-based commercial terms; scope typically reflects data volumes, endpoints, and SLAs. Contact vendor for pricing.

3. Rhapsody (Rhapsody Health Solutions)

Rhapsody is a veteran among EHR integration companies, built to “connect any source to any destination, in any format” while keeping PHI secure. It’s designed for complex health enterprises that need reliable, governed interoperability across EHRs, apps, and devices.

What it is

A healthcare interoperability platform for building, operating, and securing data flows between EHRs and external systems.

Key capabilities

• Any-to-any routing and transformation: Normalize and map disparate feeds.
• Operational visibility: Monitoring, alerting, and error handling at scale.
• Security and governance: Controls that protect personal health information.

Integrations and standards supported

Connects EHRs and ancillary systems; supports common healthcare data formats and patterns. Specific endpoints and message types are finalized during implementation.

Ideal use cases and buyers

• Health systems/IDNs: Standardize and consolidate interface operations.
• Digital health vendors: Enterprise-grade connectivity into provider environments.

Pricing and contract notes

Quote-based; terms align to scope, throughput, endpoints, and support SLAs.

4. NextGen Connect (Mirth)

NextGen Connect (often known as “Mirth”) is a well-known interface engine teams use to orchestrate, transform, and govern clinical data flows across EHRs, ancillary systems, and external apps. It’s suited to organizations that want hands-on control of mappings and routing while standardizing integrations at scale.

What it is

An interoperability engine for designing, deploying, and managing healthcare interfaces.

Key capabilities

• Any-to-any routing and transforms: Normalize disparate feeds and orchestrate workflows.
• Reusable channels and filtering: Build repeatable pipelines for common patterns.
• Operational controls: Monitoring, alerting, retry, and error handling at scale.

Integrations and standards supported

Connects to major EHRs and healthcare systems; supports common healthcare data formats and integration patterns. Specific endpoints and message types are finalized during implementation.

Ideal use cases and buyers

• Health systems/HIE teams: Centralize and govern interface operations.
• Digital health vendors: Embed an enterprise-grade engine to connect with provider environments.

Pricing and contract notes

Quote-based; commercial terms typically align to deployment scope, throughput, endpoints, and support SLAs.

5. InterSystems HealthShare and IRIS for Health

InterSystems’ HealthShare and IRIS for Health are enterprise-grade options often selected when interoperability must be standardized across complex environments. Positioned alongside leading EHR integration companies, they help teams move, normalize, and operationalize clinical and administrative data with strong governance and reliability for mission-critical workflows.

What it is

A health data and interoperability platform suite for building, running, and securing integrations and shared services across diverse healthcare systems.

Key capabilities

• Any-to-any routing and transforms: Normalize and orchestrate disparate feeds.
• Shared data services: Enable cross-system views and reuse of normalized data.
• Developer tooling and APIs: Build scalable services on a common data layer.
• Operational resilience: Monitoring, alerting, error handling, and HA options.
• Governance and security: Role-based controls and auditability for PHI.

Integrations and standards supported

Connects to major EHRs and ancillary systems; supports common healthcare data formats and integration patterns. Specific endpoints, message types, and data models are finalized during implementation.

Ideal use cases and buyers

• Health systems/IDNs: Enterprise interoperability hub or HIE backbone.
• Payers/regions: Data sharing and analytics-ready pipelines.
• Digital health vendors: Embedded enterprise deployments that require governed connectivity.

Pricing and contract notes

Quote-based enterprise licensing and support; terms vary by deployment model, throughput, modules, and SLAs.

6. Epic interoperability and Connection Hub

For organizations running Epic—or partnering with those that do—the fastest route to reliable integrations often runs through Epic’s own interoperability programs. Epic highlights options like Community Connect to extend a unified, integrated patient record to affiliates, plus resources that help health systems and partners discover, govern, and scale connections across sites.

What it is

Epic’s native interoperability programs and tooling, including Community Connect, that enable data exchange and extension of an Epic EHR to affiliated organizations.

Key capabilities

• Unified patient record: Community Connect extends a host organization’s Epic to affiliates for a single, integrated chart.
• Cross‑organization exchange: Connectivity between Epic sites and external systems governed by the host health system.
• Connection governance: Visibility, approval workflows, and operational controls managed by Epic customers.

Integrations and standards supported

Connectivity spans Epic‑to‑Epic and Epic‑to‑non‑Epic systems via approaches adopted by the host health system. Specific endpoints, message types, and exchange patterns are defined per implementation with the Epic customer.

Ideal use cases and buyers

• Health systems on Epic: Standardize and extend Epic to community sites via Community Connect.
• Affiliated/independent providers: Join a sponsor’s Epic for unified workflows and data.
• Vendors working with Epic customers: Integrate through customer‑managed connection programs.

Pricing and contract notes

Program and site specific. Contracts, fees, and timelines are typically governed by the Epic customer (host) and its connection processes; scope and SLAs are finalized during onboarding.

7. Oracle Health (Cerner Ignite APIs)

Among EHR integration companies, Oracle Health (formerly Cerner) stands out for its large acute‑care footprint and enterprise rigor. Backed by Oracle since 2022, it’s a frequent choice for large health systems and government implementations. Its API programs (often referred to as Ignite APIs) give organizations a governed path to connect applications and services to Oracle Health environments.

What it is

An Oracle Health–managed set of EHR connectivity programs and APIs that enable secure data exchange and workflow integration within Oracle Health customer environments.

Key capabilities

• Enterprise connectivity: Governed, scalable access to clinical and administrative data
• Operational controls: Monitoring, auditing, and security aligned to PHI requirements
• Customer alignment: Integrations coordinated with each health system’s policies

Integrations and standards supported

Connects to Oracle Health EHRs and ancillary systems; supports common healthcare data formats and integration patterns. Specific endpoints and message types are defined per implementation with the Oracle Health customer.

Ideal use cases and buyers

• Health systems on Oracle Health: Standardize external app connectivity
• Digital health vendors: Direct integration into Oracle Health sites at scale
• Public sector/large enterprises: Governed integrations in highly regulated settings

Pricing and contract notes

Program‑ and site‑specific, quote‑based terms. Approvals, timelines, and SLAs are coordinated with Oracle Health and the hosting customer’s security and change‑control processes.

8. Datavant

Datavant positions itself as “the fastest, easiest” way to manage healthcare data interoperability and publishes a list of EHR integrations. For buyers comparing EHR integration companies, it offers a vendor‑managed route to connect applications with provider EHRs across multiple sites while simplifying coordination.

What it is

A managed connectivity platform focused on accelerating EHR integrations.

Key capabilities

• Prebuilt EHR integrations: Catalog of connections to major systems
• Standardized onboarding: Coordinated setup and change management
• Centralized oversight: Manage and streamline data exchange projects

Integrations and standards supported

Publishes a catalog of EHR integrations; supports common healthcare data formats and integration patterns. Specific endpoints and message types are confirmed per implementation.

Ideal use cases and buyers

• Digital health vendors: One path into many EHR environments
• Health systems/IDNs: Centralize external app connectivity and oversight

Pricing and contract notes

Quote‑based; terms reflect scope, volumes, endpoints, and SLAs.

9. Particle Health

Among EHR integration companies, Particle Health is often shortlisted for API‑forward connectivity with vendor‑managed onboarding. It’s useful when speed and centralized control matter across many sites.

What it is

An API‑driven, managed connectivity platform that exchanges clinical and administrative data between apps and provider systems. It reduces custom one‑offs by standardizing setup and operations.

Key capabilities

Expect vendor‑managed coordination. Tooling standardizes data flows.

• Standardized connectivity: Centralized setup and monitoring
• Data orchestration: Transform and route common payloads
• Security controls: PHI‑grade governance

Integrations and standards supported

Connects with major EHRs and related systems; supports common healthcare data formats and patterns. Specific endpoints and message types are finalized during implementation.

Ideal use cases and buyers

Best for organizations wanting one path into many provider environments. Works when repeatable playbooks trump bespoke interfaces.

• Digital health vendors: Scale across systems
• Provider orgs: Centralize external app access

Pricing and contract notes

Quote‑based terms reflecting volumes, endpoints, and SLAs. Site approvals and change‑control can influence timelines and cost.

10. Health Gorilla

Health Gorilla is often evaluated alongside other EHR integration companies for vendor‑managed interoperability that reduces custom one‑offs. Teams look to it when they want standardized onboarding, governed data exchange, and a repeatable playbook to connect applications with provider environments across multiple sites.

What it is

A managed interoperability platform that streamlines connectivity between healthcare applications and provider systems.

Key capabilities

• Vendor‑managed onboarding: Coordinated setup and approvals across sites
• Standardized APIs and routing: Consistent data exchange patterns at scale
• Security and observability: PHI‑grade controls, monitoring, and audit trails

Integrations and standards supported

Connects with major EHRs and ancillary systems; supports common healthcare data formats and integration patterns. Specific endpoints and message types are finalized during implementation.

Ideal use cases and buyers

• Digital health vendors: One integration path into many provider environments
• Provider organizations/IDNs: Centralize and govern external app connectivity

Pricing and contract notes

Quote‑based; terms vary by scope, volumes, endpoints, and SLAs. Site approvals and change control can affect timelines.

11. Smile Digital Health (Smile CDR)

Smile Digital Health (Smile CDR) is a developer‑first health data platform that teams use to centralize and operationalize clinical data, expose APIs, and standardize integrations. Buyers shortlist it when they want a governed data layer supporting reusable services and repeatable connectivity across apps, sites, and partners. It’s often considered when organizations are modernizing legacy interfaces without losing control of mappings and security.

What it is

A health data and interoperability platform for building governed APIs and running integrations at scale.

Key capabilities

• Any‑to‑any routing and transforms: Normalize disparate feeds and orchestrate workflows.
• API enablement and data services: Expose standardized access to curated clinical data.
• Security, governance, observability: PHI‑grade controls, monitoring, and audit trails.

Integrations and standards supported

Connects to major EHRs and ancillary systems; supports common healthcare data formats and integration patterns. Specific endpoints, message types, and data models are finalized during implementation.

Ideal use cases and buyers

• Health systems/HIEs: Enterprise data layer and interoperability hub.
• Digital health vendors: Standardized API surface for provider integrations.
• Payers/analytics teams: Governed ingestion and controlled access to normalized data.

Pricing and contract notes

Quote‑based enterprise licensing and support; terms vary by modules, deployment model, throughput, endpoints, and SLAs.

12. Zus Health

Teams often shortlist Zus Health when they want a developer‑friendly, vendor‑managed path to aggregate and operationalize clinical data without standing up their own interface stack. It’s typically considered alongside other EHR integration companies for API‑forward connectivity and standardized onboarding across multiple provider sites.

What it is

An API‑centric, managed interoperability platform focused on streamlining connections between healthcare applications and provider systems while centralizing data access and governance.

Key capabilities

Expect a standardized, vendor‑managed playbook for connectivity and operations.

• API surface for clinical data: Consistent access patterns across sites
• Onboarding and coordination: Vendor‑led approvals and change control
• Security and observability: PHI‑grade controls, monitoring, and auditing

Integrations and standards supported

Connects to major EHRs and ancillary systems; supports common healthcare data formats and integration patterns. Specific endpoints and message types are finalized during implementation.

Ideal use cases and buyers

Best when speed to connect and repeatability across many sites are priorities.

• Digital health vendors: Scale integrations via a single API layer
• Provider orgs/IDNs: Centralize external app connectivity and oversight

Pricing and contract notes

Quote‑based; terms typically reflect scope, volumes, endpoints, and SLAs. Site approvals and security reviews can influence timelines and cost.

Conclusion section

The right partner depends on your job to be done: API-first networks shine for multi-site scale, interface engines fit teams wanting hands-on control, and EHR‑native programs move fastest inside a single health system. Pressure-test each vendor against your workflow surface (orders, scheduling, results, status, billing), data standards you’ll use, monitoring and SLAs, security reviews, and site-level approvals. Model total cost of ownership—including per‑interface fees, data egress, and change‑order risk—and run a pilot that proves writes, not just reads.

If your priority is EHR connectivity wrapped in patient logistics that cuts calls and accelerates discharges, consider VectorCare. With Connect plus Hub, Trust, Pay, Insights, and ADI, you get integrations and the workflows they power. Start the conversation at VectorCare.